The main focus of research is to reduce population harms caused by tobacco and other nicotine products. Our research spans clinical trials of novel smoking cessation and harm reduction interventions, policy analyses and program evaluation, descriptive studies and qualitative research. This incorporates strategies aimed at the whole population as well as targeted interventions for priority populations. The vision of our NHMRC Centre of Research Excellence on Achieving the Tobacco Endgame is to achieve a smoke-free Australia by uniting global leaders in tobacco control to develop the most rigorous tobacco endgame strategy to date, and to focus on translating this strategy into policy to maximise health gains in Australia and globally.