InterLACE: International collaboration for a Life course Approach to reproductive health and
Chronic disease Events

InterLACE provides a unique opportunity to conduct world-leading research in collaboration with key national and international investigators on women’s health studies from ten countries.

Start date: January 2012
Funding sources: National Health and Medical Research Council, Australian Research Council

The project undertakes cross-cohort research by combining data at the individual level from more than 500,000 participants from 25 existing observational studies to investigate the role of reproductive health across the life course on future chronic disease events including cardiovascular disease and type 2 diabetes mellitus.

While such research poses cross-cohort and cross-cultural challenges, InterLACE has the capability to address research questions and generate robust evidence that is not possible from any single cohort study. InterLACE also enables a detailed review of methodologies currently used in studies on women’s health that will result in recommendations for study design, menopausal symptom measures, and reporting of results to improve international and cross-cultural comparisons.

  • Australian Longitudinal Study on Women’s Health (1946-51 & 1973-78 cohort), Australia
  • Healthy Aging of Women Study, Australia
  • Melbourne Collaborative Cohort Study, Australia
  • Danish Nurse Cohort Study, Denmark
  • Women’s Lifestyle and Health Study, Sweden
  • French Three-City Study, France
  • UK Biobank, UK
  • MRC National Survey of Health and Development, UK
  • National Child Development Study, UK
  • 1970 British Cohort Study, UK
  • English Longitudinal Study of Ageing, Uk
  • UK Women’s Cohort Study, UK
  • Whitehall II Study, UK
  • Southall And Brent Revisited, UK
  • Hilo Women’s Health Study, USA
  • Study of Women’s Health across the Nation, USA
  • Seattle Midlife Women’s Health Study, USA
  • San Francisco Midlife Women’s Health Study, USA
  • Decisions at Menopause Study, USA, Lebanon, Spain & Morocco (four separate studies)
  • Japanese Nurses’ Health Study, Japan
  • Japanese Midlife Women’s Health Study, Japan
InterLACE study team map
InterLACE study team map

Publications

  • Zhu D, Chung HF, Pandeya N, Dobson AJ, Hardy R, Kuh D, Brunner EJ, Bruinsma F, Giles GG, Demakakos P, Lee JS, Mizunuma H, Hayashi K, Adami HO, Weiderpass E, Mishra GD. Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women. European Journal of Epidemiology 2019; Epub ahead of print. Available from:  https://www.ncbi.nlm.nih.gov/pubmed/3072137
  • Dunneram Y, Chung HF, Cade JE, Greenwood DC, Dobson AJ, Mitchell ES, Woods NF, Brunner EJ, Yoshizawa T, Anderson D, Mishra GD. Soy intake and vasomotor menopausal symptoms among midlife women: a pooled analysis of five studies from the InterLACE consortium. European Journal of Clinical Nutrition 2019; Epub ahead of print. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30718804
  • Mishra GD, Chung HF, Pandeya N, Kuh D, Hayashi K, Lee JS, Mizunuma H, Crawford SL, Avis NE, Gold EB, Mitchell ES, Woods NF, Anderson D, Brown DE, Sievert LL, Brunner EJ, Demakakos P, Cade JE, Greenwood DC, Giles GG, Bruinsma F, Cooper R, Hardy R, Tillin T,  Obermeyer CM, Simonsen MK, Canonico M, Ancelin ML, Schoenaker DAJM, Adami HO, Weiderpass E, Dobson AJ. Variations in reproductive events across life: a pooled analysis of data from 505,147 women across ten countries. Human Reproduction 2019; Epub ahead of print. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30835788
  • Zhu D, Chung HF, Pandeya N, Dobson AJ, JE Cade, Greenwood DC, Crawford SL, Avis NE, Gold EB, Mitchell ES, Woods NF, Anderson D, Brown DE, Sievert LL, Brunner EJ, Kuh D, Hardy R, Hayashi K, Lee JS, Mizunuma H, Giles GG, Bruinsma F, Tillin T, Simonsen MK, Adami HO, Weiderpass E, Canonico M, Ancelin ML, Demakakos P, Mishra GD. Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: a pooled analysis of individual data from 17 observational studies. PLOS Medicine 2018; 15(11):e1002704. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30481189
  • Chung HF, Pandeya N, Dobson AJ, Kuh D, Brunner EJ, Crawford SL, Avis NE, Gold EB, Mitchell ES, Woods NF,  Bromberger JT, Thurston RC, Joffe H, Yoshizawa T, Anderson D, Mishra GD. The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium. Psychological Medicine 2018; 48(15):2550-61. Available from:  https://www.ncbi.nlm.nih.gov/pubmed/29429422
  • Pandeya N, Huxley RR, Chung HF, Dobson AJ, Kuh D, Hardy R, Cade JE, Greenwood DC, Giles GG, Bruinsma F, Demakakos P, Simonsen MK, Adami HO, Weiderpass E, Mishra GD. Female reproductive history and risk of type 2 diabetes: a prospective analysis of 126,721 women. Diabetes, Obesity and Metabolism 2018; 20(9):2103-12. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29696756
  • Zhu D, Chung HF, Pandeya N, Dobson AJ, Kuh D, Crawford SL, Gold EB, Avis NE, Giles GG, Bruinsma F, Adami HO, Weiderpass E, Greenwood DC, Cade JE, Mitchell ES, Woods NF, Brunner EJ, Simonsen MK, Mishra GD. Body mass index and age at natural menopause: an international pooled analysis of 11 prospective studies. European Journal of Epidemiology 2018; 33(8):699-710. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29460096
  • Mishra GD, Pandeya N, Dobson AJ, Chung HF, Anderson D, Kuh D, Sandin S, Giles GG, Bruinsma F, Hayashi K, Lee JS, Mizunuma H,  Cade JE, Burley V, Greenwood DC, Goodman A, Simonsen MK,  Adami HO, Demakakos P, Weiderpass E. InterLACE study team. Early menarche, nulliparity, and the risk for premature and early natural menopause. Human Reproduction 2017; 32(3):679-86. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28119483
  • Mishra GD, Chung HF, Pandeya N, Dobson AJ, Jones L, Avis NE, Crawford SL, Gold EB, Brown D, Sievert LL, Brunner E, Cade JE, Burley VJ, Greenwood DC, Giles GG, Bruinsma F, Goodman A, Hayashi K, Lee JS, Mizunuma H, Kuh D, Cooper R, Hardy R, Obermeyer CM, Lee KA, Simonsen MK, Yoshizawa T, Woods NF, Mitchell ES, Hamer M, Demakakos P, Sandin S, Adami HO, Weiderpass E, Anderson D. The InterLACE study: design, data harmonization and characteristics across 20 studies on women’s health. Maturitas 2016; 92:176-85. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27621257
  • Mishra GD, Anderson D, Schoenaker DAJM, Adami HO, Avis NE, Brown D, Bruinsma F, Brunner E, Cade JE, Crawford SL, Dobson AJ, Elliott J, Giles GG, Gold EB, Hayashi K, Kuh D, Lee KA, Lee JS, Melby MK, Mizunuma H, Sievert LL, Weiderpass E. InterLACE: A new International Collaboration for a Life Course Approach to Women’s Reproductive Health and Chronic Disease Events. Maturitas 2013; 74:235-40. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23313437