The Harm Reduction for Tobacco Smokers research program aims to develop and evaluate quite smoking and harm reduction resources for tobacco smokers in general populations as well as those with co-morbid conditions such as severe mental illness and HIV. Tobacco harm reduction refers to switching partially or completely to clean nicotine products such as nicotine replacement therapy (NRT) and electronic cigarettes and is especially relevant to those smokers who are unable or unwilling to quit tobacco smoking.